Chemical name: 1, 1- two methyl dimetformin hydrochloride
Chemical structural formula:
Molecular formula: C4H11N5. HCl
Molecular weight: 165.63
This product is an enteric capsule with white particles and powder.
(1) this product is the first choice for type 2 diabetes, which is ineffective for simple diet control and physical exercise, especially type 2 diabetes, which is obese.
(2) for type 1 or type 2 diabetes, combination of insulin and this product can increase the hypoglycemic effect of insulin, reduce the dosage of insulin and prevent hypoglycemia.
(3) this product can also be combined with sulfonylurea and other oral hypoglycemic agents, with a synergistic effect.
[usage and dosage]
The treatment of diabetes should be based on the principle of individualization according to the measurement of blood glucose. Start with small doses and gradually increase the dose according to the patient's condition. The maximum recommended dose for adults was 1.8g per day. The initial amount is 0.25g (1), 2 times a day, before meals. About a week later, if the disease control is not satisfied, can be added to 3 times a day, each time 0.25g (1 grains), gradually add to the daily 1.8g, take each time.
The initial dose of children is usually 0.25g (1), 2 times a day, before meals. According to the control of blood sugar, the dosage can be increased as appropriate, the highest dose can be 1.8g per day.
The common adverse reactions include diarrhea, nausea, vomiting, fatigue, bloating, indigestion, abdominal discomfort, and headache. Other rare cases were stool abnormalities, hypoglycemia, myalgia, dizziness, dizziness, nail abnormalities, rash, sweating, abnormal taste, chest discomfort, chills, flu symptoms, hot flashes, palpitation, weight loss and so on. Metformin can reduce the absorption of vitamin B12, but rarely cause anemia. This product is rare in the range of treatment dose, causing lactic acidosis.
(1) the following situations: disable kidney disease or heart failure (shock), renal dysfunction and acute myocardial infarction caused by sepsis (serum creatinine level greater than or equal to 1.5mg/dl (male), or 1.4mg/dl (female) or abnormal creatinine clearance).
(2) congestive heart failure requiring drug treatment, and other serious heart and lung diseases.
(3) severe infection and trauma, surgical operation, low blood pressure and hypoxia, etc.
(4) a known allergy to metformin hydrochloride.
(5) acute or onic metabolic acidosis, including or without comatose diabetic ketoacidosis, and diabetes ketoacidosis need to be treated with insulin.
(7) those who receive intravascular injection of iodized contrast agents should be temporarily discontinued.
(8) the deficiency of vitamin B12 and folic acid was not corrected.